This interactive handbook, developed in collaboration with the Digital Impact Alliance (DIAL), serves as a hands-on resource to help mid-to-senior level staff of Mobile Network Operators (MNOs), National Statistical Offices (NSOs) and other interested parties understand and develop MD4D projects. DPA’s contribution to the handbook involved structuring key content and presenting use cases, lessons and experiences developed in different contexts (e.g. our work with cell-phone metadata in Colombia, Senegal, Lebanon, and the Maldives). The project also took into consideration the new demands and challenges that the COVID-19 pandemic has created for the operationalization of these data.